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Pediatr Blood Cancer. 2005 Mar;44(3):201-4.

Quality-adjusted survival: a rigorous assessment of cure after cancer during childhood and adolescence.

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  • 1Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. rbarr@mcmaster.ca


Survivors of cancer in childhood and adolescence, while increasing gratifyingly in number with ever more effective therapy, have a life expectancy that is compromised all-too-often in both duration and value as a result of adverse treatment-related sequelae. Accounting for this burden of morbidity and mortality is essential for a proper appreciation of cure. Adjusting estimates of survival by measures of its quality affords a means of accomodating this requirement. It can be accomplished by "weighting" the length of survival according to preference-based assessments of health-related quality of life (HRQL), which allow the calculation of quality-adjusted life years. Inclusion of measures of HRQL in clinical trials is imperative as we reach to the ultimate objective; the truly cured child restored to normal health.

(c) 2004 Wiley-Liss, Inc.

[PubMed - indexed for MEDLINE]
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