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J Magn Reson Imaging. 2004 Oct;20(4):595-600.

Delayed hyper-enhancement of myocardium in hypertrophic cardiomyopathy with asymmetrical septal hypertrophy: comparison with global and regional cardiac MR imaging appearances.

Author information

  • 1Department of Radiology, Nippon Medical School, Tokyo, Japan. yas-amano@nifty.com

Abstract

PURPOSE:

To evaluate the relationship between delayed hyper-enhancement of the myocardium and global and regional cardiac abnormalities in hypertrophic cardiomyopathy (HCM) with asymmetrical septal hypertrophy using magnetic resonance (MR) imaging.

MATERIALS AND METHODS:

Twenty-three patients with HCM with asymmetrical septal hypertrophy were examined using a 1.5-T MR unit. Contrast-enhanced inversion-recovery gradient-echo imaging was performed to observe the myocardial damages associated with HCM. Balanced steady-state free precession imaging was performed to assess regional wall abnormalities and ejection fraction, and black-blood fast spin-echo imaging was performed to assess left atrial diameter.

RESULTS:

Delayed hyper-enhancement of the myocardium was primarily observed in the interventricular septal wall. Septal walls with the higher transmural extent of delayed hyper-enhancement were significantly thicker at end-diastole and end-systole (P < 0.05), and tended to show a decreased percentage systolic wall thickening (P = 0.079). There were no differences in theses values between non-enhancing septal walls and septal walls with the transmural extent < 50%.

CONCLUSION:

The high transmural extent of delayed hyper-enhancement of the myocardium may reflect the severe myocardial damage associated with the regional hypertrophy and hypokinesia in HCM.

Copyright 2004 Wiley-Liss, Inc.

PMID:
15390225
[PubMed - indexed for MEDLINE]
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