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FEBS Lett. 2004 Sep 24;575(1-3):109-11.

Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides.

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  • 1Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Karolina Ășt 29, P.O. Box 7, Budapest H-1518, Hungary.


Analysis of the exon-intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.

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