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Physiology (Bethesda). 2004 Oct;19:271-6.

Why calcium-stimulated adenylyl cyclases?

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  • 1Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.

Abstract

The Ca(2+)/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca(2+) increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.

PMID:
15381755
[PubMed - indexed for MEDLINE]
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