Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Pharmacol Sci. 2004 Oct;25(10):528-35.

PKC-interacting proteins: from function to pharmacology.

Author information

  • 1Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK. a.poole@bris.ac.uk

Abstract

Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development.

PMID:
15380937
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk