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Clin Immunol. 2004 Oct;113(1):4-13.

T cells in the pathogenesis of systemic lupus erythematosus.

Author information

  • Division of Rheumatology and Immunology, Department of Medicine, University of Miami and the Miami Veterans Affairs Medical Center, Miami, FL 33136, USA. rhoffman@med.miami.edu


Recent studies in patients with systemic lupus erythematosus (SLE) have demonstrated that autoantigen-reactive T cells can be isolated from peripheral blood and that such cells can support autoantibody production ex vivo, suggesting that they may have a central role in the pathogenesis of disease. In addition, recent work has identified and characterized signaling abnormalities in T cells from SLE that may be fundamental to the disease. This review will examine the role of T cells in the pathogenesis of SLE and it will consider pathogenic mechanisms by which T cells escape normal of immunological tolerance. The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE.

[PubMed - indexed for MEDLINE]
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