Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Cell. 2004 Sep;6(3):197-8.

Mouse models of human cancer as tools in drug development.

Author information

  • 1Memorial Sloan-Kettering Cancer Center, Departments of Surgery (Neurosurgery), Neurology, and Cell Biology and Genetics, 1275 York Avenue, New York, NY 10021, USA.


Histologically accurate mouse models of human cancers generated by somatic or germline genetic modification strategies recapitulate the genetic alterations found in human tumors. In this issue of Cancer Cell, test a novel signaling inhibitor in a genetically defined mouse medulloblastoma and show the utility of these models in drug development. They demonstrate that targeting signaling components downstream of tumor initiating mutations can be an effective therapeutic strategy for solid tumors.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk