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1: Nat Struct Mol Biol. 2004 Oct;11(10):1021-2. Epub 2004 Sep 19.Click here to read Links

Molecular structure of human geminin.

Okorokov AL, Orlova EV, Kingsbury SR, Bagneris C, Gohlke U, Williams GH, Stoeber K.

Bloomsbury Centre of Structural Biology, Birkbeck College, Malet Street, London, WC1E 7HX, UK.

The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first molecular structure of human geminin, determined by EM and image processing at a resolution of 17.5 A. The geminin molecule is a tetramer formed by two dimers with monomers interacting via coiled-coil domains. The unusual structural organization of geminin provides molecular insight into its bifunctional nature.

PMID: 15378034 [PubMed - indexed for MEDLINE]

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