Format

Send to

Choose Destination
See comment in PubMed Commons below
J Bioenerg Biomembr. 2004 Aug;36(4):375-9.

MPTP as a mitochondrial neurotoxic model of Parkinson's disease.

Author information

  • 1Department of Neurology, Columbia University, New York, New York 10032, USA. sp30@columbia.edu

Abstract

1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk