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Biomed Microdevices. 2004 Sep;6(3):177-82.

Microneedle insertion force reduction using vibratory actuation.

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  • 1Department of Bioengineering, The Pennsylvania State University, University Park 16802, USA.

Abstract

The effect of vibratory actuation on microneedle insertion force was investigated. Hollow micro hypodermic injection needles were fabricated by a two-wafer polysilicon micromolding process. A vibratory actuator operating in the kHz range was coupled with the hypodermic microneedles. The force to insert microneedles into excized animal tissue was measured with a load cell. Results showed a greater than 70% reduction in microneedle insertion force by using vibratory actuation. The application of vibratory actuation provides a promising method to precisely control the microneedle insertion forces to overcome microneedle structural material limitations, minimize insertion pain, and enhance the efficiency of drug delivery.

PMID:
15377826
[PubMed - indexed for MEDLINE]
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