Stroke. 2004 Nov;35(11 Suppl 1):2623-7. Epub 2004 Sep 16.

Atherosclerosis of cerebral arteries in Alzheimer disease.

Roher AE, Esh C, Rahman A, Kokjohn TA, Beach TG.

Source

Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Ariz 85351, USA. alex.roher@sunhealth.org

Abstract

A growing body of evidence suggests that vascular disease underlies Alzheimer dementia. Atherosclerotic lesions in the circle of Willis and large leptomeningeal vessels were quantified and found to correlate with Alzheimer disease (AD) clinical diagnosis and neuropathology. We hypothesize that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions. Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia.

PMID:: 15375298; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Alzheimer's Disease - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles. [Acta Neuropathol. 2007]
Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles.
Beach TG, Wilson JR, Sue LI, Newell A, Poston M, Cisneros R, Pandya Y, Esh C, Connor DJ, Sabbagh M, et al. Acta Neuropathol. 2007 Jan; 113(1):13-21. Epub 2006 Sep 20.
Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia. [Alzheimers Dement. 2011]
Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia.
Roher AE, Tyas SL, Maarouf CL, Daugs ID, Kokjohn TA, Emmerling MR, Garami Z, Belohlavek M, Sabbagh MN, Sue LI, et al. Alzheimers Dement. 2011 Jul; 7(4):436-44. Epub 2011 Mar 9.
Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease. [Arterioscler Thromb Vasc Biol....]
Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease.
Roher AE, Esh C, Kokjohn TA, Kalback W, Luehrs DC, Seward JD, Sue LI, Beach TG. Arterioscler Thromb Vasc Biol. 2003 Nov 1; 23(11):2055-62. Epub 2003 Sep 25.
Review Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease. [Neurol Res. 2004]
Review Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease.
Kalback W, Esh C, Castaño EM, Rahman A, Kokjohn T, Luehrs DC, Sue L, Cisneros R, Gerber F, Richardson C, et al. Neurol Res. 2004 Jul; 26(5):525-39.
Review Neuropathological evaluation of mixed dementia. [J Neurol Sci. 2007]
Review Neuropathological evaluation of mixed dementia.
Jellinger KA, Attems J. J Neurol Sci. 2007 Jun 15; 257(1-2):80-7. Epub 2007 Feb 26.

See reviews... See all...

Cited by 14 PubMed Central articles

Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project. [J Alzheimers Dis. 2013]
Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project.
Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Ohya Y, Willcox DC, Dodge HH. J Alzheimers Dis. 2013 Jan 1; 34(1):273-9.
Cerebral blood flow in Alzheimer's disease. [Vasc Health Risk Manag. 2012]
Cerebral blood flow in Alzheimer's disease.
Roher AE, Debbins JP, Malek-Ahmadi M, Chen K, Pipe JG, Maze S, Belden C, Maarouf CL, Thiyyagura P, Mo H, et al. Vasc Health Risk Manag. 2012; 8:599-611. Epub 2012 Oct 23.
The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. [ISRN Neurol. 2011]
The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease.
Carter CJ. ISRN Neurol. 2011; 2011:394678. Epub 2011 Jul 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Atherosclerosis of cerebral arteries in Alzheimer disease.
Atherosclerosis of cerebral arteries in Alzheimer disease.
Stroke. 2004 Nov ;35(11 Suppl 1):2623-7. Epub 2004 Sep 16 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Atherosclerosis of cerebral arteries in Alzheimer disease.

Source

Abstract

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 14 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information