Neurosystems Center, Cancer Center and Department of Preventive Sciences, University of Minnesota, Minneapolis, MN 55455, USA. manty001@tc.umn.edu <manty001@tc.umn.edu>
The neurokinin-1 receptor is expressed by lamina I projection neurons of the spinal cord that are crucial for regulating pain behavior. These neurons are nocispecific, support long-term potentiation and appear to downregulate the K(+)-Cl(-) exporter channel KCC2 following peripheral nerve damage, leading to increased excitability. These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic.