The Py235 proteins: glimpses into the versatility of a malaria multigene family

Anne Charlotte Grüner; Georges Snounou; Katy Fuller; William Jarra; Laurent Rénia; Peter R Preiser

doi:10.1016/j.micinf.2004.04.004

The Py235 proteins: glimpses into the versatility of a malaria multigene family

Microbes Infect. 2004 Jul;6(9):864-73. doi: 10.1016/j.micinf.2004.04.004.

Authors

Anne Charlotte Grüner¹, Georges Snounou, Katy Fuller, William Jarra, Laurent Rénia, Peter R Preiser

Affiliation

¹ Département d'Immunologie, Institut Cochin, Inserm U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France.

PMID: 15374009
DOI: 10.1016/j.micinf.2004.04.004

Abstract

Py235 rhoptry proteins, encoded by a multigene family of the rodent malaria parasite Plasmodium yoelii, combine a functional role in invasion with one of immune evasion, and have homologues in malaria parasites of humans. Investigations of Py235 are summarised and the perspectives for dissecting the molecular and biological mechanisms underlying these crucial phenomena are discussed.

Publication types

Review

MeSH terms

Animals
Erythrocytes / parasitology
Humans
Malaria / parasitology
Multigene Family*
Plasmodium yoelii / pathogenicity*
Protozoan Proteins / genetics*

Substances

Protozoan Proteins
rhoptry associated protein, Plasmodium