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Nature. 2004 Sep 16;431(7006):350-5.

The functions of animal microRNAs.

Author information

  • Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA (e-mail: vra@dartmouth.edu)

Abstract

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

PMID:
15372042
[PubMed - indexed for MEDLINE]
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