Mol Biol Cell. 2004 Dec;15(12):5659-69. Epub 2004 Sep 15.

Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress.

Source

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. mshapira@stanford.edu

Erratum in

Mol Biol Cell. 2005 Feb;16(2):1011.

Abstract

The effects of oxidative stress on yeast cell cycle depend on the stress-exerting agent. We studied the effects of two oxidative stress agents, hydrogen peroxide (HP) and the superoxide-generating agent menadione (MD). We found that two small coexpressed groups of genes regulated by the Mcm1-Fkh2-Ndd1 transcription regulatory complex are sufficient to account for the difference in the effects of HP and MD on the progress of the cell cycle, namely, G1 arrest with MD and an S phase delay followed by a G2/M arrest with HP. Support for this hypothesis is provided by fkh1fkh2 double mutants, which are affected by MD as we find HP affects wild-type cells. The apparent involvement of a forkhead protein in HP-induced cell cycle arrest, similar to that reported for Caenorhabditis elegans and human, describes a potentially novel stress response pathway in yeast.

PMID:: 15371544; [PubMed - indexed for MEDLINE]
PMCID: PMC532044

Free PMC Article

Images from this publication.See all images (7) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

GM-46406/GM/NIGMS NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Related citations

Hydrogen peroxide causes RAD9-dependent cell cycle arrest in G2 in Saccharomyces cerevisiae whereas menadione causes G1 arrest independent of RAD9 function. [J Biol Chem. 1998]
Hydrogen peroxide causes RAD9-dependent cell cycle arrest in G2 in Saccharomyces cerevisiae whereas menadione causes G1 arrest independent of RAD9 function.
Flattery-O'Brien JA, Dawes IW. J Biol Chem. 1998 Apr 10; 273(15):8564-71.
The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. [EMBO J. 2000]
The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF.
Pic A, Lim FL, Ross SJ, Veal EA, Johnson AL, Sultan MR, West AG, Johnston LH, Sharrocks AD, Morgan BA. EMBO J. 2000 Jul 17; 19(14):3750-61.
The Isw2 chromatin-remodeling ATPase cooperates with the Fkh2 transcription factor to repress transcription of the B-type cyclin gene CLB2. [Mol Cell Biol. 2007]
The Isw2 chromatin-remodeling ATPase cooperates with the Fkh2 transcription factor to repress transcription of the B-type cyclin gene CLB2.
Sherriff JA, Kent NA, Mellor J. Mol Cell Biol. 2007 Apr; 27(8):2848-60. Epub 2007 Feb 5.
Review Microarrays and cell cycle transcription in yeast. [Curr Opin Cell Biol. 2000]
Review Microarrays and cell cycle transcription in yeast.
Futcher B. Curr Opin Cell Biol. 2000 Dec; 12(6):710-5.
Review Global control of gene expression in yeast by the Ccr4-Not complex. [Gene. 2003]
Review Global control of gene expression in yeast by the Ccr4-Not complex.
Collart MA. Gene. 2003 Aug 14; 313:1-16.

See reviews... See all...

Cited by 12 PubMed Central articles

The forkhead transcription factor Hcm1 promotes mitochondrial biogenesis and stress resistance in yeast. [J Biol Chem. 2010]
The forkhead transcription factor Hcm1 promotes mitochondrial biogenesis and stress resistance in yeast.
Rodriguez-Colman MJ, Reverter-Branchat G, Sorolla MA, Tamarit J, Ros J, Cabiscol E. J Biol Chem. 2010 Nov 19; 285(47):37092-101. Epub 2010 Sep 16.
Reverse engineering dynamic temporal models of biological processes and their relationships. [Proc Natl Acad Sci U S A. 2010]
Reverse engineering dynamic temporal models of biological processes and their relationships.
Ramakrishnan N, Tadepalli S, Watson LT, Helm RF, Antoniotti M, Mishra B. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12511-6. Epub 2010 Jun 22.
Multi-dimensional correlations for gene coexpression and application to the large-scale data of Arabidopsis. [Bioinformatics. 2009]
Multi-dimensional correlations for gene coexpression and application to the large-scale data of Arabidopsis.
Kinoshita K, Obayashi T. Bioinformatics. 2009 Oct 15; 25(20):2677-84. Epub 2009 Jul 20.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
GEO DataSets
Gene expression and molecular abundance data reported in the current articles that are also included in the curated Gene Expression Omnibus (GEO) DataSets.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Disruption of yeast forkhead-associated cell cycle transcription by oxidative st...
Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress.
Mol Biol Cell. 2004 Dec ;15(12):5659-69. Epub 2004 Sep 15 .

PubMed
The 'Severe Hypertensive Illness in Pregnancy' (SHIP) audit: promoting quality c...
The 'Severe Hypertensive Illness in Pregnancy' (SHIP) audit: promoting quality care using a high risk monitoring chart and eclampsia treatment pack.
J Obstet Gynaecol. 2002 Jul ;22(4):346-52.

PubMed
Three-dimensional structural dynamics of myosin V by single-molecule fluorescenc...
Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization.
Nature. 2003 Mar 27 ;422(6930):399-404.

PubMed
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.
J Biol Chem. 2003 Jul 11 ;278(28):25752-7. Epub 2003 May 2 .

PubMed
Clinical trial: short- and long-term benefit of relaxation training for irritabl...
Clinical trial: short- and long-term benefit of relaxation training for irritable bowel syndrome.
Aliment Pharmacol Ther. 2007 Sep 15 ;26(6):943-52.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: