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    J Soc Biol. 2004;198(2):133-7.

    [Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]

    [Article in French]

    Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C.

    UFR Biomédicale des Saints Pères, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, FRE 2718 CNRS, U648 INSERM, 45, rue des Saints-Pères, 75270 Paris Cedex 06.

    Cellular signaling pathways induced by growth-factor receptors are frequently deregulated in cancer. Anti-tumor agents that inhibit their enzymatic tyrosine kinase activity have been designed and are now used in human chemotherapy. We propose here an alternative way to interrupt over-expressed signaling by inhibiting protein-protein interactions that involve either the over-expressed proteins or proteins located downstream. The adaptor protein Grb2 over-expressed in connection with HER2/ErbB2/neu in Ras signaling pathway was chosen as a target. Peptides with very high affinity for Grb2 were rationally designed from structural data. Their capacity to interrupt the signaling pathway, their anti-proliferative activity as well as their potential anti-tumor properties are described.

    PMID: 15368963 [PubMed - indexed for MEDLINE]

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