Pediatr Nephrol. 2004 Nov;19(11):1194-201. Epub 2004 Sep 9.

Genetic disorders of transporters/channels in the inner ear and their relation to the kidney.

Peters TA, Monnens LA, Cremers CW, Curfs JH.

Source

Department of Otorhinolaryngology, University Medical Center Nijmegen, Philips van Leydenlaan 15, 6525 EX Nijmegen, The Netherlands. t.peters@kno.umcn.nl.

Abstract

Inner ear physiology is reviewed with emphasis on features common to renal physiology. Genetic disorders in transporters/channels for chloride (ClC-K), bicarbonate (Cl(-)/HCO(3)(-) exchanger), protons (H(+)-ATPase), sodium (ENaC, NKKC1, NBC3, NHE3), potassium (KCNQ1/KCNE1, Kcc4), and water (AQP4) in the inner ear and their relation to the kidney are discussed. Based on data from human disorders (with or without mouse counterparts) and mouse models (without human counterparts) this article focuses on the involvement of these transporters/channels in hearing loss.

PMID:: 15365806; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Membrane Transport Proteins

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Kidney Diseases - MedlinePlus Health Information

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