Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2004 Oct;20(10):491-7.

Bringing the role of mRNA decay in the control of gene expression into focus.

Author information

  • 1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.


The process of mRNA decay is integral to the post-transcriptional control of gene expression. The enzymes of the pathway have been identified, and now several laboratories have found that the mRNA decay machinery is localized to discrete cytoplasmic foci whose existence had not been suspected previously. In addition, we can now see that mRNA turnover is a means to coordinate gene expression, first through integration with control of transcription, export and translation of mRNAs, and second through enabling mRNAs involved in similar processes to decay at similar rates. These and other aspects of the field are discussed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk