Curr Opin Cell Biol. 2004 Oct;16(5):580-9.

Eph/ephrin signaling in morphogenesis, neural development and plasticity.

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Department of Molecular Neurobiology, Max-Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Munich-Martinsried, Germany. rklein@neuro.mpg.de

Abstract

Ephrins are cell-surface-tethered ligands for Eph receptors, the largest family of receptor tyrosine kinases. During development, the Eph/ephrin cell communication system appears to influence cell behavior such as attraction/repulsion, adhesion/de-adhesion and migration, thereby influencing cell fate, morphogenesis and organogenesis. During adulthood, the Eph/ephrin system continues to play roles in tissue plasticity, for example in shaping dendritic spines during neuronal plasticity. Mechanistically, Eph-ephrin repulsive behavior appears to require ligand-receptor internalization and signaling to Rho GTPases.

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Eph/ephrin signaling in morphogenesis, neural development and plasticity.

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