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Dev Cell. 2004 Sep;7(3):287-8.

Lipid phase perturbations and the unfolded protein response.

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  • 1Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

Abstract

Recent studies of the consequences of ganglioside accumulation in lysosomal storage disease and free cholesterol accumulation in cell membranes in atherosclerosis suggest an unexpected link between perturbation of the endoplasmic reticulum membrane's lipid phase, induction of the unfolded protein response, and cell death.

PMID:
15363403
[PubMed - indexed for MEDLINE]
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