Display Settings:

Format

Send to:

Choose Destination
Environ Health. 2004 Sep 13;3(1):8.

Anogenital distance in human male and female newborns: a descriptive, cross-sectional study.

Author information

  • 1National Institute of Public Health, Av. Universidad 655, Col. Santa Ma. Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico. esalazar@correo.insp.mx

Abstract

BACKGROUND:

In animal studies of the effects of hormonally active agents, measurement of anogenital distance (AGD) is now routine, and serves as a bioassay of fetal androgen action. Although measurement of AGD in humans has been discussed in the literature, to our knowledge it has been measured formally in only two descriptive studies of females. Because AGD has been an easy-to-measure, sensitive outcome in animals studies, we developed and implemented an anthropometric protocol for measurement of AGD in human males as well as females.

METHODS:

We first evaluated the reliability of the AGD measures in 20 subjects. Then measurements were taken on an additional 87 newborns (42 females, 45 males). All subjects were from Morelos, Mexico.

RESULTS:

The reliability (Pearson r) of the AGD measure was, for females 0.50, and for males, 0.64. The between-subject variation in AGD, however, was much greater than the variation due to measurement error. The AGD measure was about two-fold greater in males (mean, 22 mm) than in females (mean, 11 mm), and there was little overlap in the distributions for males and females.

CONCLUSION:

The sexual dimorphism of AGD in humans comprises prima facie evidence that this outcome may respond to in utero exposure to hormonally active agents.

PMID:
15363098
[PubMed - indexed for MEDLINE]
PMCID:
PMC521084
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk