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Biochem Biophys Res Commun. 2004 Aug 13;321(1):1-6.

Transcription, translation, degradation, and circadian clock.

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  • 1College of Life Science, Sichuan University, 29 Wang-Jiang Road, Chengdu 610064, PR China.


Synthesis and degradation of mRNA together with synthesis and degradation of corresponding protein, this four-step-expression confers great fitness to all organisms. Transcription rate and mRNA stability both are essential for circadian expression of clock genes. In many cases, transcription rates and half-lives of mRNAs and corresponding proteins are not necessarily tightly linked with each other. The methods for measuring four-step-expression should be carefully selected and the experimental conditions should be strictly controlled.

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