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J Microbiol. 2004 Jun;42(2):147-51.

Identification of sigmaB-dependent promoters using consensus-directed search of Streptomyces coelicolor genome.

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  • 1School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, Korea.


SigmaB plays an important role in both osmoprotection and proper differentiation in Streptomyces coelicolor A3(2). We searched for candidate members of the sigmaB regulon from the genome database, using the consensus promoter sequence (GNNTN14-16GGGTAC/T). The list consists of 115 genes, and includes all the known sigmaB target genes and many other genes whose functions are related to stress protection and differentiation.

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