Curr Psychiatry Rep. 2004 Oct;6(5):339-46.

Recent advances in the treatment of opiate addiction.

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Behavioral Health Service (116), Veterans Affairs Medical Center, Room B-228, University and Woodland Avenues, Philadelphia, PA 19104, USA. fudala_p@mail.trc.upenn.edu

Abstract

Although addiction to heroin and other opiates is a major public health issue in the United States and many other countries, advances in pharmacologic and nonpharmacologic treatment have been made. Some of these advances represent a major shift from traditional treatment philosophies, whereas others are characterized by more subtle, though important, improvements. This review discusses recent advances in opiate-addiction treatment in the context of three main domains: the use of buprenorphine and buprenorphine/naloxone in an office-based paradigm, psychosocial treatment and the addressing of medical and psychiatric comorbidity, and harm reduction strategies.

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Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. [N Engl J Med. 2003]
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