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Acta Psychiatr Scand. 2004 Oct;110(4):243-56.

Hypofrontality in schizophrenia: a meta-analysis of functional imaging studies.

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  • 1Fulbourn Hospital, Cambridge, UK.

Abstract

OBJECTIVE:

Hypofrontality is not a well-replicated finding in schizophrenia either at rest or under conditions of task activation.

METHOD:

Studies comparing whole brain and frontal blood flow/metabolism in schizophrenic patients and normal controls were pooled. Voxel-based studies were also combined to examine the pattern of prefrontal activation in schizophrenia.

RESULTS:

Whole brain flow/metabolism was reduced in schizophrenia to only a small extent. Resting and activation frontal flow/metabolism were both reduced with a medium effect size. Duration of illness significantly moderated resting hypofrontality, but the moderating effects of neuroleptic treatment were consistent with an influence on global flow/metabolism only. Pooling of voxel-based studies did not suggest an abnormal pattern of activation in schizophrenia.

CONCLUSION:

Meta-analysis supports resting hypofrontality in schizophrenia. Task-activated hypofrontality is also supported, but there is little from voxel-based studies to suggest that this is associated with an altered pattern of regional functional architecture.

PMID:
15352925
[PubMed - indexed for MEDLINE]
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