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Trends Cell Biol. 2004 Sep;14(9):474-8.

Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

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  • 1Department of Biological Sciences, University of Pittsburgh, 274 Crawford Hall, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA.


The failure of secreted proteins to fold results in their retrotranslocation from the endoplasmic reticulum (ER) and degradation by the proteasome in a process called "ER-associated degradation" (ERAD). Two recent studies indicate that ERAD substrates are targeted to different pathways depending on the topology of the substrate and the subcellular location of the misfolded domain.

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