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J Am Anim Hosp Assoc. 2004 Sep-Oct;40(5):376-84.

Comparison of serological tests for the detection of natural heartworm infection in cats.

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  • 1Department of Small Animal, Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA.


Serological tests were performed on 380 cats with necropsy-confirmed heartworm disease to compare the performance of currently available commercial laboratory and point-of-care heart-worm serological tests in a heartworm-endemic area. Overall, antigen tests detected 79.3% to 86.2% of heartworm infections and were highly specific. Most cats with false-negative antigen tests had a single male worm. Antibody tests detected 62.1% to 72.4% of heartworm infections and had a wider range of false-positive results (1.4% to 19.1%) than antigen tests (0.3% to 2.0%). Serological tests for feline heartworm infection varied in diagnostic performance. Combining results from antigen and antibody tests achieved greater sensitivity than using either test alone.

[PubMed - indexed for MEDLINE]
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