Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Stem Cells Dev. 2004 Aug;13(4):372-81.

Neural differentiation from embryonic stem cells: which way?

Author information

  • 1Department of Anatomy, School of Medicine, Waisman Center, Wicell Institute, University of Wisconsin, Madison, WI 53705, USA.

Abstract

Embryonic stem (ES) cells can in theory produce all cell types of a living organism while renewing themselves with a stable genetic background. These unique features make ES cells a favorable tool for biomedical researches as well as a potential source for therapeutic application. A first step for approaching to ES cells is the directed differentiation to cells of interest, such as the neural cell lineage. Here, we summarize the up and down sides of each category of neural differentiation protocols that have so far been used in mouse and human ES cells, and introduce an efficient and plausible method used in our laboratory for derivation of neuroectodermal cells from human ES cells. This synthesis has led to our suggestions on issues for future design of neural differentiation protocols.

PMID:
15345131
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc.
    Loading ...
    Write to the Help Desk