Predicting and validating microRNA targets.

545 Life Sciences Addition, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3200, USA. lai@fruitfly.org

Given that microRNAs select their targets by nucleotide base-pairing, it follows that it should be possible to find microRNA targets computationally. There has been considerable progress, but assessing success and biological significance requires a move into the 'wet' lab.

PMID: 15345038 [PubMed - indexed for MEDLINE]

PMCID: PMC522861