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    Brain Res. 2004 Sep 24;1021(2):292-6.

    Alpha2-adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex.

    Mondaca M, Hernández A, Pérez H, Valladares L, Sierralta W, Fernández V, Soto-Moyano R.

    Source

    Laboratory of Hormones and Receptors, Institute of Nutrition and Food Technology (INTA), University of Chile, P.O. Box 138-11, Santiago, Chile.

    Abstract

    Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i.p.) increased neocortical LTP in a dose-dependent fashion. These effects could be related to the reported disruptive and facilitatory actions induced on memory formation by pretreatment with alpha(2)-adrenoceptor agonists and antagonists, respectively.

    PMID:
    15342280
    [PubMed - indexed for MEDLINE]

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