Send to

Choose Destination
See comment in PubMed Commons below
Bioorg Med Chem Lett. 2004 Oct 4;14(19):4915-8.

The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors.

Author information

  • 1Athersys, Inc., 3201 Carnegie Ave., Cleveland, OH 44115, USA.


There have been several recent reports of chemopotentiation via inhibition of DNA repair processes. Flap endonuclease 1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage. In this report, we describe the identification and SAR of a series of 2,4-diketobutyric acid FEN1 inhibitors.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk