Curr Biol. 2004 Sep 7;14(17):R719-21.

Tumor metastasis: a new twist on epithelial-mesenchymal transitions.

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Robert H. Lurie Comprehensive Cancer Center, Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.

Abstract

Epithelial-mesenchymal transitions are essential for normal embryonic development and for progression of non-invasive tumor cells into malignant, metastatic carcinomas. Twist, an important regulator of morphogenesis in the embryo, has recently been implicated in the onset of invasive behavior during tumor progression.

PMID:: 15341765; [PubMed - indexed for MEDLINE]

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