[Analysis of the glutathione S-transferase P1 gene Ile105Val polymorphism in the patients with sporadic motor neuron disease from Russia]

A L Zherebtsova; M I Shadrina; G N Levitskiĭ; N I Levintskaia; A V Alekhin; P A Slominskiĭ; V I Skvortsova; S A Limborskaia

[Analysis of the glutathione S-transferase P1 gene Ile105Val polymorphism in the patients with sporadic motor neuron disease from Russia]

Genetika. 2004 Jun;40(6):850-2.

[Article in Russian]

Authors

A L Zherebtsova, M I Shadrina, G N Levitskiĭ, N I Levintskaia, A V Alekhin, P A Slominskiĭ, V I Skvortsova, S A Limborskaia

PMID: 15341277

Abstract

Ile105Val polymorphism in exon 5 of glutathione S-transferase (GSTP1) gene was examined in a group of patients with motor neuron disease (MND) and control sample. No statistically significant differences in the allele and genotype frequency distributions between the samples examined were demonstrated. We conclude that Ile105Val polymorphism is not associated with the risk of the disease development in the patients from Russia with sporadic form of MND.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Base Sequence
DNA Primers
Gene Frequency
Genotype
Glutathione Transferase / chemistry
Glutathione Transferase / genetics*
Humans
Isoleucine / genetics*
Motor Neuron Disease / enzymology
Motor Neuron Disease / genetics*
Polymorphism, Genetic*
Russia
Valine / genetics*

Substances

DNA Primers
Isoleucine
Glutathione Transferase
Valine