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Trends Biochem Sci. 1992 Jan;17(1):32-6.

Topography of glycosylation reactions in the endoplasmic reticulum.

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  • 1Department of Biochemistry and Molecular Biology, University of Massachusetts Medical Center, Worcester 01655.


A variety of distinct protein glycosylation reactions occur in the endoplasmic reticulum (ER) of eukaryotic cells. In some instances, both the proteins to be glycosylated and the precursor sugar donors must be translocated across the membrane from the cytoplasm to the lumen of the ER. Elucidation of the individual steps in each of the glycosylation pathways has revealed the topographic complexity of these reactions.

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