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Rheumatol Int. 2005 May;25(4):311-3. Epub 2004 Aug 25.

Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy.

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  • 1Hospital for Rheumatic Diseases, Hanyang University, 17 Haengdang-Dong, Sungdong-Gu, Seoul 133-792, Korea.


Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (total dose 1702.5 mg). This may be the first such case reported in the literature.

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