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Trends Microbiol. 2004 Sep;12(9):401-4.

Antibiotic-induced lateral transfer of antibiotic resistance.

Author information

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030-3411, USA. hastings@bcm.tmc.edu

Abstract

As do many temperate bacteriophages, integrating conjugative elements (ICEs) recruit the SOS DNA damage response to mobilize themselves from the bacterial chromosome and infect other cells. This transfers resistance to multiple antibiotics. Several commonly used antibiotics induce the SOS response, potentially hastening genetic change and the evolution to resistance of pathogenic populations. The use of such antibiotics should be reconsidered.

PMID:
15337159
[PubMed - indexed for MEDLINE]
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