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    Sleep Med Rev. 2004 Oct;8(5):355-66.

    Pharmacotherapy for cataplexy.

    Houghton WC, Scammell TE, Thorpy M.

    Orphan Medical, Inc., Medical Affairs, 13911 Ridgedale Drive, Suite 250, Minnetonka, MN 55305, USA. whoughton@orphan.com

    A variety of medications representing several major drug classes improve cataplexy in patients with narcolepsy. These include aminergic reuptake inhibitors such as venlafaxine and clomipramine as well as sodium oxybate. This review is intended to familiarize readers with the safety and efficacy of these medications, thus enabling clinicians to optimize their management of cataplexy.

    PMID: 15336236 [PubMed - indexed for MEDLINE]

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    Patient drug information

    • Clomipramine (Anafranil®)

      Clomipramine is used to treat people with obsessive-compulsive disorder (a condition that causes repeated unwanted thoughts and the need to perform certain behaviors over and over). Clomipramine is in a group of medicati...

    • Venlafaxine (Effexor®, Effexor® XR)

      Venlafaxine is used to treat depression. Venlafaxine extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety diso...

    • Sodium Oxybate (Xyrem®)

      Sodium oxybate is used to prevent attacks of cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) in patients who have narcolepsy (a sleep disorder that may cause extreme sleepiness, sudd...

    • Source: AHFS Consumer Medication Information

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