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Am J Psychiatry. 1992 May;149(5):694-6.

Abnormal diurnal variation in circulating natural killer cell phenotypes and cytotoxic activity in major depression.

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  • 1Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill.


This investigation tested the hypothesis that depressed patients have abnormal diurnal variation of natural killer (NK) cell measures. The diurnal variation of levels of Leu-11 NK cells and NK cytotoxic activity was significantly less in 24 patients with major depression than in 24 normal comparison subjects. These findings provide evidence that aspects of immune, as well as neural and endocrine, chronobiology are abnormal in depression.

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