Briarane diterpenes from two species of octocorals, Ellisella sp. and Pteroeides sp

Chiaki Tanaka; Yumiko Yamamoto; Masahito Otsuka; Junichi Tanaka; Toshio Ichiba; Gerard Marriott; Rachmaniar Rachmat; Tatsuo Higa

doi:10.1021/np049923o

Briarane diterpenes from two species of octocorals, Ellisella sp. and Pteroeides sp

J Nat Prod. 2004 Aug;67(8):1368-73. doi: 10.1021/np049923o.

Authors

Chiaki Tanaka¹, Yumiko Yamamoto, Masahito Otsuka, Junichi Tanaka, Toshio Ichiba, Gerard Marriott, Rachmaniar Rachmat, Tatsuo Higa

Affiliation

¹ Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

PMID: 15332856
DOI: 10.1021/np049923o

Abstract

Eight new briarane diterpenes (1-4, 7-10) have been isolated from two species of octocorals and the structures elucidated by spectroscopic analysis. Two diterpenes (2, 3) from the gorgonian Ellisella sp. inhibited cytokinesis, causing multinuclei formation on NBT-II cells, while a known briarane (12) from the sea pen Pteroeides sp. showed reversal of multidrug resistance.

MeSH terms

Animals
Cnidaria / chemistry*
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Resistance, Multiple
Drug Screening Assays, Antitumor
Humans
Japan
KB Cells
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Diterpenes