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    Antimicrob Agents Chemother. 2004 Sep;48(9):3583-5.

    Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin.

    Raad II, Hanna HA, Hachem RY, Dvorak T, Arbuckle RB, Chaiban G, Rice LB.

    Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. iraad@mdanderson.org

    The susceptibility of 135 vancomycin-resistant Enterococcus faecium bacteremic isolates to linezolid and quinupristin-dalfopristin was determined. All were susceptible to linezolid, while 88% were susceptible to quinupristin-dalfopristin prior to the clinical use of the drugs at our hospital. More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene.

    PMID: 15328133 [PubMed - indexed for MEDLINE]

    PMCID: 514771

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    Patient drug information

    • Vancomycin (Vancocin®)

      Vancomycin is used to treat colitis (inflammation of the intestine caused by certain bacteria) that may occur after antibiotic treatment. Vancomycin is in a class of medications called glycopeptide antibiotics. It works ...

    • Linezolid (Zyvox®)

      Linezolid is used to treat infections, including pneumonia, urinary tract infections, and infections of the skin and blood. Linezolid is in a class of antibacterials called oxazolidinones. It works by stopping the growth...

    • Source: AHFS Consumer Medication Information

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