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    Neurology. 2004 Aug 24;63(4):718-20.

    Randomized pilot trial of high-dose betaINF-1a in patients with inclusion body myositis.

    Muscle Study Group.

    Source

    Neuromuscular Disease Center, 601 Elmwood Avenue, Box 673, Rochester, NY 14642-8673. Rabi_Tawil@URMC.Rochester.edu

    Abstract

    Beta-interferon-1a (betaINF-1a) is well tolerated at low dose (30 microg IM/week) in inclusion body myositis (IBM). The authors investigated the safety and tolerability of high-dose (60 microg IM/week) betaINF-1a in a randomized, placebo-controlled trial in IBM. Twenty-seven of the 30 subjects enrolled completed the study. The adverse event profile was similar for the placebo and betaINF-1a groups. betaINF-1a, at a dose of 60 microg IM/week, is well tolerated in IBM, but no differences in muscle strength or mass were observed between the placebo and betaINF-1a groups at 6 months in this pilot study.

    PMID:
    15326251
    [PubMed - indexed for MEDLINE]

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