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Chem Biol. 2004 Aug;11(8):1037-42.

Protein motions promote catalysis.

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  • 1Département de Chimie, Université de Montréal, Montréal, Québec, H3C 3J7, Canada.


A relationship between molecular dynamics motions of noncatalytic residues and enzyme activity has recently been proposed. We present examples where mutations either near or distal from the active site residues modify internal enzyme motion with resulting modification of catalysis. A better understanding of internal protein motions correlated to catalysis will lead to a greater insight into enzyme function.

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