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    Am J Clin Pathol. 2004 Aug;122(2):275-89.

    Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S).

    Jiang Z, Woda BA, Wu CL, Yang XJ.

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    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA.

    Abstract

    The recent discovery of the overexpression of P504S/alpha-methylacyl coenzyme A racemase (AMACR) in prostate cancer is a successful example of translating an advanced molecular finding into clinical practice. AMACR (P504S) has been proven to be one of the few biomarkers that can help distinguish cancer from benign cells, with high sensitivity and specificity for prostate carcinoma. It is the first gene identified by the analysis of complementary DNA microarray profiles from prostate tissue to be used as a tissue tumor marker in clinical practice and to improve the diagnosis of prostate cancer. This review focuses on the study of AMACR (P504S) expression in prostate cancer, premalignant lesions, benign prostate tissues, and other normal and malignant tissues and a discussion of its clinical usefulness. We emphasize the interpretation of the AMACR immunohistochemical results in routine surgical pathology practice and also discuss the potential future applications of this marker and the possible role of AMACR in the pathogenesis of cancer development.

    PMID:
    15323145
    [PubMed - indexed for MEDLINE]
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      Cited by 7 PubMed Central articles

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        NKX3.1 as a marker of prostatic origin in metastatic tumors.
        Gurel B, Ali TZ, Montgomery EA, Begum S, Hicks J, Goggins M, Eberhart CG, Clark DP, Bieberich CJ, Epstein JI, et al. Am J Surg Pathol. 2010 Aug; 34(8):1097-105.
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        Mello BP, Abrantes EF, Torres CH, Machado-Lima A, Fonseca Rda S, Carraro DM, Brentani RR, Reis LF, Brentani H. Nucleic Acids Res. 2009 May; 37(8):2607-17. Epub 2009 Mar 6.
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