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Diabet Med. 2004 Sep;21(9):1049-50.

A case of secondary diabetes mellitus with acromegaly improved by pioglitazone.

Author information

  • 1Third Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan. 2315com@med.nihon-u.ac.jp

Abstract

AIM:

The acromegaly patient was diagnosed with Type 2 diabetes mellitus. His HbA1c was 10.6% and fasting blood glucose (FBG) 15.3 mmol/l. We prescribed glibenclamide (10 mg/day), but his HbA1c and FBG remained high. At this stage, treatment with short-acting insulin was instigated at a dose of 20 U/day. However, the patient's blood glucose level remained unsatisfactory. We tried using pioglitazone.

METHOD:

Pioglitazone was prescribed at 30 mg/day in combination with the insulin.

RESULTS:

The FBG and HbA1c value decreased to 7.2 mmol/l and 7.3%, respectively, within 2 months and insulin was discontinued. Pioglitazone alone was able to control the FBG level.

CONCLUSIONS:

Pioglitazone treatment might be considered as a choice for similar cases of diabetes secondary to acromegaly.

PMID:
15317614
[PubMed - indexed for MEDLINE]
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