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Can Fam Physician. 2004 Jul;50:993-7.

Bone health. New role for vitamin K?

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  • 1FEAST Enterprises, Oshawa, Ont.

Abstract

OBJECTIVE:

To assess growing evidence that vitamin K (phylloquinone) plays an important role in bone health and, subsequently, in prevention of osteoporotic fractures.

QUALITY OF EVIDENCE:

We searched MEDLINE from January 1972 to December 2002 using the key words vitamin K and bone health. We reviewed 30 articles that seemed relevant or had a human focus. All evidence can be categorized as level II.

MAIN MESSAGE:

Evidence suggests that dietary phylloquinone intake of <100 microg daily might not be optimal for bone health. Low intake of vitamin K could contribute to osteoporosis and subsequent fracture due to the undercarboxylation of osteocalcin.

CONCLUSION:

Family physicians need to be aware of the importance of encouraging adequate vitamin K intake, particularly among institutionalized elderly people, to prevent increased bone resorption. Further study is needed to determine the exact role of vitamin K in bone metabolism, and methods of assessing vitamin K requirements need to be standardized.

PMID:
15317231
[PubMed - indexed for MEDLINE]
PMCID:
PMC2214630
Free PMC Article
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