Br J Cancer. 2004 Oct 4;91(7):1380-3.

Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene.

Berge G, Øvrebø S, Eilertsen E, Haugen A, Mollerup S.

Source

Department of Toxicology, National Institute of Occupational Health, PO Box 8149 Dep, N-0033 Oslo, Norway.

Abstract

Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[a]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.

PMID:: 15316568; [PubMed - indexed for MEDLINE]
PMCID:: PMC2409901

Free PMC Article

Images from this publication.See all images (1) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Lung Cancer - MedlinePlus Health Information

Molecular Biology Databases

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells. [Int J Cancer. 2001]
Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells.
Mollerup S, Ovrebø S, Haugen A. Int J Cancer. 2001 Apr 1; 92(1):18-25.
The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. [Mutagenesis. 2011]
The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene.
Einem Lindeman T, Poirier MC, Divi RL. Mutagenesis. 2011 Sep; 26(5):629-35. Epub 2011 Jun 13.
Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells. [Br J Cancer. 2004]
Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells.
Berge G, Øvrebø S, Botnen IV, Hewer A, Phillips DH, Haugen A, Mollerup S. Br J Cancer. 2004 Jul 19; 91(2):333-8.
Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung. [Lung Cancer. 2004]
Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung.
Berge G, Mollerup S, ØVrebø S, Hewer A, Phillips DH, Eilertsen E, Haugen A. Lung Cancer. 2004 Sep; 45(3):289-97.
Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. [Toxicol In Vitro. 2006]
Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.
Harrigan JA, McGarrigle BP, Sutter TR, Olson JR. Toxicol In Vitro. 2006 Jun; 20(4):426-38. Epub 2005 Sep 28.

See reviews... See all...

Cited by 3 PubMed Central articles

Review What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. [PLoS One. 2011]
Review What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.
Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, et al. PLoS One. 2011; 6(6):e19881. Epub 2011 Jun 16.
Review Resveratrol: a review of preclinical studies for human cancer prevention. [Toxicol Appl Pharmacol. 2007]
Review Resveratrol: a review of preclinical studies for human cancer prevention.
Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL. Toxicol Appl Pharmacol. 2007 Nov 1; 224(3):274-83. Epub 2007 Jan 3.
Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice. [Food Chem Toxicol. 2007]
Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice.
Horn TL, Cwik MJ, Morrissey RL, Kapetanovic I, Crowell JA, Booth TD, McCormick DL. Food Chem Toxicol. 2007 Jan; 45(1):55-63. Epub 2006 Aug 8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice expos...
Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene.
Br J Cancer. 2004 Oct 4 ;91(7):1380-3.

PubMed
Determination of food specific IgE levels over time can predict the development ...
Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy.
J Allergy Clin Immunol. 2004 Aug ;114(2):387-91.

PubMed
Effect of dehydration on thirst and drinking during immersion in men.
Effect of dehydration on thirst and drinking during immersion in men.
J Appl Physiol. 1992 Jan ;72(1):128-34.

PubMed
Cancer and interstitial lung disease.
Cancer and interstitial lung disease.
Curr Opin Pulm Med. 2004 Sep ;10(5):425-34.

PubMed
Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoep...
Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope m30 in critically ill patients.
Shock. 2004 Sep ;22(3):218-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information