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    Cell. 2004 Aug 20;118(4):409-18.

    Stem cells and cancer; the polycomb connection.

    Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M.

    Source

    The Netherlands Cancer Institute, Department of Molecular Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

    Abstract

    Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in cancer development and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer.

    PMID:
    15315754
    [PubMed - indexed for MEDLINE]

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