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Arch Neurol. 2004 Aug;61(8):1237-40.

Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL.

Author information

  • 1Service de Neurologie, Assistance Publique--Hôpitaux de Paris, Hôpital Lariboisière, Paris, France. katayoun.vahedi@lrb.ap-hop-paris.fr

Abstract

BACKGROUND:

Migraine with aura (MA) is one of the clinical hallmarks of CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a small vessel disease of the brain caused by mutations in the NOTCH3 gene, but its exact mechanisms are unknown.

OBJECTIVES:

To describe the patterns of MA in CADASIL and to compare brain magnetic resonance signal abnormalities between CADASIL patients with and without MA.

DESIGN:

Comparison of brain magnetic resonance signal abnormalities between cases and controls.

SETTING:

Patients with CADASIL seen at Lariboisière Hospital.

PATIENTS:

Forty-one CADASIL patients with MA and 31 age-matched CADASIL controls without MA.

RESULTS:

The mean age at onset of MA was significantly younger in women compared with men and occurred a mean of 15 years prior to stroke onset. A majority of patients (56%) reported at least 1 migraine attack with atypical aura. All CADASIL patients either with or without MA had white matter signal abnormalities on T2-weighted imaging. There was no difference in the frequency and distribution of brain signal abnormalities between CADASIL patients with and without MA.

CONCLUSIONS:

In CADASIL, MA is characterized by an unusually high frequency of attacks of migraine with atypical aura. The distribution and extent of magnetic resonance signal abnormalities did not differ according to migraine phenotype.

PMID:
15313840
[PubMed - indexed for MEDLINE]
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