Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2004 Sep;20(9):403-7.

How much expression divergence after yeast gene duplication could be explained by regulatory motif evolution?

Author information

  • 1Department of Genetics, Development & Cell Biology, Center for Bioinformatics and Biological Statistics, Iowa State University, IA 50011, USA.

Abstract

We used the yeast genome sequences of gene families, microarray profiles and regulatory motif data to test the current wisdom that there is a strong correlation between regulatory motif structure and gene expression profile. Our results suggest that duplicate genes tend to be co-expressed but the correlation between motif content and expression similarity is generally poor, only approximately 2-3% of expression variation can be explained by the motif divergence. Our observations suggest that, in addition to the cis-regulatory motif structure in the upstream region of the gene, multiple trans-acting factors in the gene network can influence the pattern of gene expression significantly.

PMID:
15313547
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk