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Curr Opin Struct Biol. 2004 Aug;14(4):413-9.

Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily.

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  • 1Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK.


Structural knowledge of the major facilitator superfamily has dramatically increased during the past year with the emergence of the structures of three members of this family of transporters. All three structures reveal 12 transmembrane helices forming two distinct domains, and could imply that members of this superfamily have preserved both secondary and tertiary structure elements during evolution.

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